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Lyme guide

How Lyme testing works

A screen first, then a confirmation if needed. Why timing matters more than people think.

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Lyma follows the two-tier approach in NICE guideline NG95 and HSE guidance. Every sample goes to ArminLabs, an accredited lab in Germany.

  1. First, a screen (ELISA)

    Checks for IgM and IgG antibodies to the Lyme bacteria.
  2. Borderline or Detected? Confirm it

    An immunoblot on the same sample checks for antibodies to specific Lyme proteins. Nothing extra for you to do.
  3. Not detected but early? Repeat it

    If your sample was taken within 4 weeks of symptoms starting, a second test 4 to 6 weeks later can give a clearer answer.

Why the calendar matters

  • Day 0: the bite. Remove the tick, photograph it and log where you were. No test yet.
  • Weeks 1 to 4: watch for a rash. A spreading red rash means book a doctor's visit; it can be diagnosed on sight.
  • From week 4: if symptoms appear, an antibody test is more likely to give a true answer.
  • Week 12 and on: still unwell? A doctor can order a confirmatory test or look for other causes.

A clinician reads every result alongside your symptoms. Results can be wrong both ways, which is why no result is released without a clinician note.

Reviewed by Dr Aoife Smith, Clinical lead, on 11 November 2026. Next review 11 May 2027. Based on NICE guideline NG95 and HSE guidance.

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